Hi Erik,
Although basic the question is quite
interesting. Interesting because basics have created all question marks?
Let's analyze this question through basic dialogues: 1) Would you like to
get around 15 % w/w loss in final batch output? 2) Don't you compensate
for LOD for actives? 3) Why treat actives and non-actives differently? $)
Why not apply the rule of thumb of compensating for LOD whether it's
actives or other wise. The answer to your question lies in above answers.
Best regards,
U. G. Barad (M. Pharm., Ph. D.)
ushakal@sancharnet.in
|