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Insoluble impurities in parenteral drugs

Just joined the group and am looking forward to some hopefully 
valuable interactions with  reg affairs colleagues.  Thanks in 
advance for any input. My question is:  Is anyone aware of any 
guidances or  have had FDA interactions regarding quantitation and 
allowable levels of submicron size insoluble impurities in 
parenteral products?

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David Korman
dkorman@elancorp.com
Elan Pharmaceutical Technologies

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