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[RegAffairs]USP versus in-house API specification

For  drug product/drug substance having USP orificial monograph 
effective currently please clarify with respect to following with 
respect to US ANDAs and DMF.
1. Is it possible that I can claim the API inhouse despite of having 
monograph in USP.
2. Is it possible that one can claim API in-house and product as "USP".
3. What are the obligation to ANDA holder in case during submission 
there was no USP monograph exist for drug substance and drug product 
but after approval monograph appeared for both the drug substance and 
drug product. Where shall I find the reference to these obligations.

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Kams
rules200012@yahoo.co.in


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