Re: Syringe Barrel Siliconization
Pharmaceutical Sci-Tech: Re: Syringe Barrel Siliconization
PharmTech (PharmTech@pharmweb1.man.ac.uk)
Fri, 27 Sep 1996 09:21:01 -0400
There is a method using extraction with solvent followed by Atomic
Absorption.There are problems with the burner clogging up but it can
be done.The use of visualising techniques (talc,Tollen's reagent) and
Functional testing i.e Break-loose and Extrusion force is a lot
easier.Try Dow Corning for assistance.
The specific reference is:
Miller,J.R,Helprin J.J,Finlayson J.S.
"Silicone lubricant flushed from disposable syringes:Determination by
Atomic Absorption Spectrophotmetry."
Journal of Pharmaceutical Sciences,58,(4),pp 455-456 (April 1969),
There is also a brief but interesting study on Adsorption on silicone
treated surfaces:
T.Mizutani "Adsorption of some antibiotics and other drugs on silicone
coated glass surfaces".
J.Pharm.Pharmacol 1982,34:pp 608-609.
Best regards,
Ron Jones (rjones@novo.dk)
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Subject: Syringe Barrel Siliconization
Author: "PharmTech" <PharmTech@ade5.pa.man.ac.uk> at Internet
Date: 26-09-96 16.02
Syringe barrels are treated with silicone by suppliers. Does anyone
know a method of quantifying total silicone on the inside of the
barrel? This would identify a total silicone load available to the
contents. Does anyone have any suggestions, methods or labs, that
could be of use?
Richard Hunt : RHUNT@BRACCO.COM