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Drug Alert - USA - FDA report dated 26 February 1997

February 26, 1997                                 97-09

RECALLS AND FIELD CORRECTIONS:  DRUGS -- CLASS II ===========
_______________
PRODUCT        Doxycycline Hyclate, 100 mg Capsules, USP, in
               bottles of 50 and 500, Rx, a broad spectrum
               antibiotic.  Recall #D-118-7.
CODE           Various labels and lot numbers as follows:
               (a) Aligen Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 50 capsules
               distributed by Aligen Independent
               Laboratories, Inc., Jackson Hole, Wyoming
               Lots:  55301M3  EXP 10/98 and 55310M3 EXP
               10/98
               (b) Aligen Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 500 capsules
               distributed by Aligen Independent
               Laboratories, Inc., Jackson Hole, Wyoming
               Lots:  55304H3 EXP 08/98 and 55303M3 EXP 10/98
               (c) Doxychel Doxycycline Hyclate 100 mg
               Capsules in bottles of 50 capsules, Rachelle
               Laboratories, Inc., Culver, Indiana, Lot:
               55303R3 EXP 11/98
               (d) Doxychel Doxycycline Hyclate 100 mg
               Capsules in bottles of 500 capsules, Rachelle
               Laboratories, Inc., Culver, Indiana,
               Lots:  55302M3 EXP 10/98, 55305M3 EXP 10/98,
               55306M3 EXP 10/98, 55308M3 EXP 10/98, 55309M3
               EXP 10/98, and 55308R3 EXP 11/98
               (e) Geneva Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 50 capsules
               distributed by Geneva Pharmaceuticals, Inc.,
               Broomfield, Colorado, Lots:  55310M3 EXP 10/98
               and 55306R3 EXP 11/98
               (f) Geneva Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 500 capsules
               distributed by Geneva Pharmaceuticals, Inc.,
               Broomfield, Colorado, Lots:  55307H3 EXP 08/98
               and 55303R3 EXP 11/98
               (g) Halsey Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 50  capsules,
               Halsey Drug Co., Inc., Brooklyn, New York
               Lots:  55306H3 EXP 08/98, 55310M3 EXP 10/98,
               55303R3 EXP 11/98, and 55306R3 EXP 11/98
               (h) Halsey Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 500  capsules,
               Halsey Drug Co., Inc., Brooklyn, New York
               Lots:  55306H3 EXP 08/98, 55304H3 EXP 08/98,
               55307H3 EXP 08/98, 55308H3 EXP 08/98, 55301K3
               EXP 09/98 and 55307A4 EXP 11/98
               (i) Major Doxycycline Hyclate 100 mg capsules,
               USP in bottles of 50 capsules, Major
               Pharmaceutical Corp., Chicago, Illinois, and
               labeled "Manufactured by Halsey Drug Co.,
               Inc., Brooklyn, N.Y." Lots:  55306H3 EXP
               08/98, 55309H3 EXP 08/98, 55310M3 EXP
               10/98 and 55306R3 EXP 11/98
               (j) Major Doxycycline Hyclate 100 mg capsules,
               USP in bottles of 500  capsules distributed by
               Major Pharmaceutical Corp., Chicago, Illinois
               and labeled "Manufactured by Halsey Drug Co.,
               Inc., Brooklyn, N.Y."  Lots:  55307H3 EXP
               08/98, 55308H3 EXP 08/98, 55302M3 EXP 10/98
               and 55306R3 EXP 11/98
               (k) Mason Doxycycline Hyclate 100 mg capsules,
               USP in bottles of 500 capsules distributed by
               Mason Distributors, Inc., Hialean, Florida,
               and labeled "Mfd. by Halsey Drug Co., Inc.,
               Brooklyn, N.Y."  Lots:  55303M3 EXP 10/98 and
               55301R3 EXP 11/98
               (l) Moore Doxycycline Hyclate 100 mg capsules,
               USP in bottles of 50 capsules distributed by
               h.l. Moore Drug Exchange, New Britain,
               Connecticut, and labeled "Mfg. by Halsey Drug
               Co., Inc., Brooklyn, N.Y." Lots:  55306H3 EXP
               08/98, 55309H3 EXP 08/98, 55310M3 EXP 10/98
               and 55306R3 EXP 11/98
               (m) Moore Doxycycline Hyclate 100 mg capsules,
               USP in bottles of 500 capsules distributed by
               h.l. Moore Drug Exchange, New Britain,
               Connecticut, and labeled "Mfg. by Halsey Drug
               Co., Inc., Brooklyn, N.Y."  Lots:  55304H3 EXP
               08/98, 55308H3 EXP 08/98, 55301K3 EXP 09/98,
               55302M3 EXP 10/98
               (n) Parmed Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 50 capsules
               distributed by Parmed Pharmaceuticals, Inc.,
               Niagara Falls, New York, and labeled "Mfg. by:
               Halsey Drug Co., Inc., Brooklyn, N.Y."
               Lot:  55310M3 EXP 10/98
               (o) Parmed Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 500 capsules
               distributed by Parmed Pharmaceuticals, Inc.,
               Niagara Falls, New York, and labeled "Mfg. by:
               Halsey Drug Co., Inc., Brooklyn, N.Y."
               Lot:  55302M3 EXP 10/98
               (p) Qualitest Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 50 capsules and
               labeled "Mfg. for: Qualitest Products, Inc.,
		Huntsville, Alabama. Mfg. by: Halsey Drug
               Co, Inc., Brooklyn, N.Y." Lots:  55309H3 EXP
               08/98, 55310M3 EXP 10/98 and 55306R3 EXP 11/98
               (q) Qualitest Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 500 capsules and
               labeled "Mfg. for: Qualitest Products, Inc.,
               Huntsville, Alabama. Mfg. by: Halsey Drug Co.,
               Inc., Brooklyn, N.Y." Lots:  55306H3 EXP
               08-98, 55303M3 EXP 10/98, 55301R3 EXP 11/98,
               55303R3 EXP 11/98 and 55306R3 EXP 11/98
               (r) URL Doxycycline Hyclate 100 mg capsules,
               USP in bottles of 50 capsules and labeled
               "Manufactured for United Research
               Laboratories, Inc., Bensalem, Pennsylvania
               Mfd. By Halsey Drug Co., Inc., Brooklyn, N.Y."
               Lots:  55306H3 EXP 08/98 and 55309H3 EXP 08/98
               (s) URL Doxycycline Hyclate 100 mg capsules,
               USP in bottles of 500 capsules and labeled
               "Manufactured for United Research
               Laboratories, Inc., Bensalem, Pennsylvania
               Mfd. By Halsey Drug Co., Inc., Brooklyn, N.Y."
               Lots:  55308H3 EXP 08/98 and 55301K3 EXP 09/98
               (t) Warner Chilcott Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 50 capsules and
               labeled "Manufactured for: Warner Chilcott
               Labs, Div of Warner-Lambert Co., Morris
               Plains, New Jersey By: Halsey Drug Co., Inc.,
               Brooklyn, NY" Lots:  94953W EXP 08/98 and
               55301M3 EXP 10/98
               (U) Warner Chilcott Doxycycline Hyclate 100 mg
               capsules, USP in bottles of 500 capsules and
               labeled "Manufactured for: Warner Chilcott
               Labs, Div of Warner-Lambert Co., Morris
               Plains, New Jersey By: Halsey Drug Co., Inc.,
               Brooklyn, NY" Lots:  92183W EXP 08/98, 55304M3
               EXP 10/98 and 55311R3 EXP 11/98.
MANUFACTURER   Houba, Inc., a subsidiary of Halsey Drug
               Company, Inc., Culver, Indiana.
RECALLED BY    Manufacturer, by  letter dated January 3,
               1997.  Firm-initiated recall ongoing.
DISTRIBUTION   Nationwide.
QUANTITY       12 million capsules were distributed.
REASON         Stability is not assured through expiration
               date (capsules may be excessively brittle).


RECALLS AND FIELD CORRECTIONS:  DRUGS -- CLASS III ==========
_______________
PRODUCT        Nitrostat Sublingual Tablets, 0.4 mg
               (Nitroglycerin Tablets USP), in bottles of 25,
               Rx indicated for the acute relief of an attack
               or prophylaxis of angina pectoris due to
               coronary artery disease.  Recall #D-119-7.
                             -5-_CODE           Lot #01385F EXP 7/97.
MANUFACTURER   Warner Lambert Company, Fajardo, Puerto Rico.
RECALLED BY    Parke-Davis, Division of Warner Lambert
               Company, Morris Plains, New Jersey, by letter
               on January 28, 1997.  Firm-initiated recall
               ongoing.
DISTRIBUTION   Nationwide.
QUANTITY       23,750 bottles were distributed.
REASON         Product lacks stability (failed content assay
               at the 15-month stability timepoint -- 86.6%;
               SPEC is 90-110%).





Alan W Davidson
General Secretary, International Pharmaceutical Federation
a.davidson@fip.nl or visit our web site at
http://www.pharmweb.net/pwmirror/pw9/fip/pharmweb92.html



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