Physiological models in pharmacokinetics
AB and BE, Engineering Sciences, Dartmouth College, USA
Brief Career Details
Assistant Professor and Instructor, Radiation Oncology, Harvard Medical School, 1995-1998
D.A. Berk, F. Yuan, M. Leunig, R.K. Jain. (1997). Direct in vivo measurement of targeted binding in a human tumor xenograft. Proc. Natl. Acad. Sci. USA 94:1785ñ1790.
M.E. Johnson, D.A. Berk, D. Blankschtein, D.E. Golan, R.K. Jain, and R. Langer. (1996). Lateral diffusion of small compounds in human stratum corneum and model bilayer systems. Biophysical J. 71:2656-2668.
J. Baish, Y. Gazit, D.A. Berk, M. Nozue, L.T. Baxter, and R.K. Jain. (1996). Role of tumor vascular architecture in nutrient and drug delivery: An invasion percolation based network model. Microvascular Research 51:327-346.
M.A. Swartz, D.A. Berk, and R.K. Jain. (1996). Transport in Lymphatic Capillaries: I. Macroscopic Measurement using Residence Time Distribution Analysis, Am. J. Physiology 270:H324-H329.
D.A. Berk, M.A. Swartz, A.J. Leu, and R.K. Jain. (1996). Transport in Lymphatic Capillaries: II. Microscopic Velocity Measurement with Fluorescence Recovery After Photobleaching, Am. J. Physiology 270:H330-337.
E.M. Johnson, D.A. Berk, R.K.Jain, and W.M. Deen. (1996). Hindered diffusion in agarose gels: Test of effective medium model. Biophysical J. 70:1017-1026.
Y. Gazit, D.A. Berk, M. Leunig, L.T. Baxter, and R.K. Jain. (1995). Scale-invariant behavior and vascular network formation in normal and tumor tissue. Physical Review Letters 75:2428-2431.
M. Leunig, F. Yuan, L.E. Gerweck, D.A. Berk, and R.K. Jain. (1995) Quantitative analysis of angiogenesis and growth of bone: Effect of indomethacin exposure in a combined in vitro- in vivo approach. Research in Experimental Medicine 195:275-288.
F. Yuan, M. Dellian, D. Fukumura, M. Leunig, D.A. Berk, V.P. Torchilin, and R.K. Jain. (1995). Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Research. 55:3752-3756.
M. Leunig, F. Yuan, L. Gerweck, D. Berk, and R. Jain. (1994). Angiogenesis and Growth of Isografted Bone: Quantitative In Vivo Assay in Nude Mice, Laboratory Investigation 71:300-307.
F. Yuan, M. Leunig, S.K. Huang, D.A. Berk, D. Papahadjopoulos, and R.K. Jain. (1994). Microvascular Permeability and Interstitial Penetration of Sterically Stabilized (Stealth) Liposomes, Cancer Research 54:3352-3356.
A.J. Leu, D.A. Berk, F. Yuan, and R.K. Jain. (1994). Flow velocity in the superficial lymphatic network of the mouse tail, Am. J. Physiology (Heart Circul. Physiol. 36) H1507-H1513.
E.M Johnson., D.A. Berk, R.K. Jain, and W.M. Deen. (1994). Diffusion and partitioning of proteins in charged agarose gels. Biophysical J. 68:1561-8.
F. Yuan, M. Leunig, D.A. Berk, and R.K. Jain. (1993). Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice, Microvascular Research 45:269-289.
D.A. Berk, F. Yuan, M. Leunig, and R.K. Jain. (1993). Fluorescence Photobleaching with Spatial Fourier Analysis: Measurement of Diffusion in Light-scattering Media, Biophysical J.65:2428-2436.
Opportunities for postgraduate and postdoctoral research may be available in the following areas:
© 2001 School of Pharmacy and Pharmaceutical Sciences, University of Manchester