D J Clarke BSc, PhD(Wales) Tel: +44 (0)161 275 2486 FAX: +44 (0)161 275 2396 E-mail: DClarke@fs1.pa.man.ac.uk

Delivery of biologicals (peptides, proteins, DNA)

Bioresponsive liposomes (redox, pH, enzyme, bioaffinity)

Biomimetic peptides (cloaking, cytolytic, anti-microbial, intracellular trafficking, toxins)

Immuno-camouflage and targeting

Molecular diagnostics/screening (ultrasensitive detection, fluorescence)

Biophysical methods (light scattering, flow cytometry, dielectrics, ultrasonics)

Imaging (high resolution optical, sub-micron sensing assemblies)

Smart delivery systems (integration of IT and diagnostics)

R&D is conducted by a well established interdisciplinary team with experts in synthetic and peptide chemistry, microbiology and applied physics (especially optoelectronic/laser & nanotechnology methods) with experience of transferring developments to exploitation by small companies and industry. Facilities include Category 2+ containment, clean room and hazardous chemistry laboratories.

University of Wales in Microbiology (BSc, PhD; 1970-1976).

After continuing post-doctoral work (anti-bacterial polypeptides, transport, ATPases) with Prof JG Morris FRS, in 1980, he became Biotechnology Manager for Datron (a UK/US precision measurement/data systems group), where he was responsible for biotechnology sales and leading R&D into a new venture. He moved to the Centre for Microbiology & Research (CAMR, a biopharmaceutical production & microbiological research agency of the UK Dept. of Health) in 1984 to develop and lead a major (>25 staff) industry/government programmes in enabling technology (process control, laser, diagnostic and sensor systems). This resulted in a range of developments with industry, including development of new small companies winning SMART Awards. He was seconded to the Laboratory of the Government Chemist (LGC) as Head of Strategic Research in 1990 to start a new group concerned with analytical separation/sample processing and miniaturisation. He returned to CAMR as Head of Detection (liposomal diagnostics and vaccine delivery, ultrasonic separation/PCR, nanotechnology), where he also became research committee chairman (research strategy) and co-ordinated diagnostics/detection (~£1.25 M pa programme). He has over 100 publications and over 20 patents across a range of disciplines relevant to the delivery and detection of biological materials.