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A J D'Emanuele BPharm(London) PhD(Bath) MRPharmS CChem FRSC
Tel: +44 (0)7092 030763
FAX: +44 (0)7092 030763
E-mail: Antony@DEmanuele.net

Biography

Tony D'Emanuele is a senior lecturer in pharmaceutics at the School of Pharmacy and Pharmaceutical Sciences, University of Manchester. After graduating from the School of Pharmacy, University of London in 1984, Tony undertook his postgraduate studies at the University of Bath in the area of responsive electrophoretic drug delivery. Tony took up his current appointment after an eighteen-month postdoctoral fellowship at the Massachusetts Institute of Technology where he investigated the use of ultrasound to modulate drug release from biodegradable implants.

Tony's research interests focus on the delivery of bioactive molecules. His major area of interest concerns the development of pulsatile and responsive drug delivery systems. This work involves the novel application of polymers (including dendrimers and biodegradable polymers) to the development of delivery systems where release is responsive to a patient's varying requirements. A second major interest involves the delivery of genes into cells by means of sonication. In addition to his scientific interests, Tony is also interested in information technology and was responsible for the creation of PharmWeb, the first structured pharmaceutical information resource on the Internet.

Whilst at Manchester Tony has been a visiting scientist at the Department of Pharmacy, University of S?o Paulo and also the Department of Chemical Engineering, Massachusetts Institute of Technology. Tony has been invited to give over 50 lectures, has received four prizes, has one patent, and is the author of over 90 publications. Tony is presently Chairman of the UK-Ireland Controlled Release Society.


Research

Controlled and responsive drug delivery systems:
??Chronotherapeutics
??Biodegradable polymers
??Liquid crystalline systems
??Dendrimers
??Microencapsulation
Cell transformation
Environmental scanning electron microscopy (ESEM)
Applications of the Internet - creator of PharmWeb


Teaching

Physical Pharmacy - colloids, suspensions, emulsions, rheology
Pharmacy Practice
Controlled Drug Delivery - chronotherapeutics, pulsed and responsive drug delivery, implants, biodegradable polymers


Administration

Secretary of Research Executive
Member of the Staff/Postgraduate Committee
Member of the Computer Committee
Member of the Managing Agency of the Pharmaceutical Industry Advanced Training Programme (PIAT)
Leader of Research Group on the PIAT Directorate
Chairman of the UK-Ireland Controlled Release Society (UKICRS)
Director and Co-ordinator of PharmWeb


Qualifications

BPharm (Hons) First Class, University of London, 1984
PhD, University of Bath, 1989


Society Membership

American Association of Pharmaceutical Scientists
American Chemical Society, Polymer Division
Controlled Release Society
International Pharmaceutical Federation
Royal Pharmaceutical Society of Great Britain
Fellow of the Royal Society of Chemistry
Society for General Microbiology
UK-Ireland Section of the Controlled Release Society


Brief Career Details

Appointments
Senior Lecturer, School of Pharmacy and Pharmaceutical Sciences (1998 - present)
Lecturer, School of Pharmacy and Pharmaceutical Sciences (1990 - 1998)
Visiting scientist, Department, University of Sao Paulo, Brazil (1994)
Visiting scientist, Department of Chemical Engineering, Massachusetts Institute of Technology, U.S.A. (1990 - 1991)
Postdoctoral research associate, Department of Chemical Engineering, Massachusetts Institute of Technology, U.S.A. (1989 - 1990)

Awards
International Pharmaceutical Federation Pen Award (1998)
Lilly Prize for Pharmaceutical Exellence (1995)
Whittet Award (1989)
ICI Award (1984)


Selected Recent Publications

Milhem, O. M., Myles, C., McKeown, N. B., Attwood, D., D'Emanuele, A.
Polyamidoamine Starburst dendrimers as solubility enhancers
Int. J. Pharm, in press.

Li, S. K., D'Emanuele, A.
Novel thermoresponsive composite membranes.
Proceed. 6th UKCRS Symposium on Controlled Drug Delivery, 4, 2000.

Milhem, O. M., Myles, C., McKeown, N. B., Attwood, D., D'Emanuele, A.
Polyamidoamine dendrimers as drug solubility enhancers.
Proceed. 6th UKCRS Symposium on Controlled Drug Delivery, 12, 2000.

McCann, D., Heatley, F., DEmanuele, A.
Characterisation of eroding polyanhydride copolymers by liquid-state and solid-state 1H and 2H NMR spectroscopy.
Polymer, 40, 2151-2162, 1999.

Heatley, F., Humadi, M., Law, R. V., DEmanuele, A.
Erosion of a 1,3-bis(p-carboxyphenoxy)propane-sebacic acid poly(anhydride) copolymer by water vapour studied by 1H and 13C solid-state NMR spectroscopy.
Macromolecules, 31, 3832-3838, 1998.

DEmanuele. A., Dennis, A., McCann, D., Muir, I.
The imaging of a controlled release pellet formulation using scanning electron microscopy - potential for artefact generation.
Pharm. Dev. Tech., 3, 135-139, 1998.

Akbari, H., DEmanuele, A., Attwood, D.
Effect of fabrication technique on the erosion characteristics of polyanhydride matrices.
Pharm. Dev. Tech, 3, 251-259, 1998.

Akbari, H., DEmanuele, A., Attwood, D.
Effect of geometry on the erosion characteristics of polyanhydride matrices.
Int. J. Pharm, 160, 83-89, 1998.

Watson, S.J., Gleeson, H.F., DEmanuele, A. Serak, S., Grozhik, V.
A Study of In Situ Isothermal Phase Transitions in Photochromic Liquid Crystals,
Proc. Photonic West, Optoelectronics, 3282 76-85, 1998.

Li, S. K., DEmanuele, A.
The effect of thermal cycling on the temperature dependent swelling behaviour of poly(N-isopropylacrylamide) hydrogels,
Proceed. 4th UKCRS Symposium on Controlled Drug Delivery, 4, 1998.

Watson, S.J., Gleeson, H.F., DEmanuele, A. Serak, S., Grozhik, V.
A study of photochromic azobenzene liquid crystals as controlled release drug delivery systems,
17th International Liquid Crystal Conference, 1998.

Erfan, M., DEmanuele, A, Collett, J.H.
The influence of gamma irradiation on the release of 4-amino-3-nitro-benzonitrile from polyanhydride matrices,
Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 25, 723-724, 1998.

D'Emanuele, A.,
The Internet
Pharm. J., 260, 26-28, 1998.

D'Emanuele, A.,
The Internet: A tool for delivering and exchanging information
Int. Pharm. J., 10, 129-134, 1998

Wyber, J-A., Andrews, J., DEmanuele, A.
The use of sonication for the efficient delivery of plasmid DNA into cells.
Pharm. Res., 14, 754-760, 1997.

D'Emanuele, A.,
Responsive Polymeric Drug Delivery Systems: meeting the Patient's Need.
Clin. Pharmacokinetics, 31(4), 1-5, 1996.

Other Publications

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? 2001 School of Pharmacy and Pharmaceutical Sciences, University of Manchester