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S Freeman BSc PhD(Leicester)
Tel: +44 (0)161 275 2366
FAX: +44 (0)161 275 2396
E-mail: SFreeman@fs1.pa.man.ac.uk

Research

Synthesis and evaluation of biologically active inositol phosphates
Prodrug methodology for the cellular delivery of drugs
Synthesis and evaluation of carbohydrate phosphate analogues
Synthesis of inhibitors and alternative substrates for enzymatic reactions, including cancer chemotherapy targets

Teaching

Organic and medicinal chemistry

Administration

Secretary to the School's Board
Member of the Postgraduate Affairs Group
Member of the Lister Institute
Committee Member of the Academic Pharmacy Group, Royal Pharmaceutical Society

Qualifications

BSc Chemistry (Hons) First Class, Leicester University, 1982
PhD, Organophosphorus Chemistry, Leicester University, 1985

Society Membership

Royal Society of Chemistry, CChem, MRSC

Brief Career Details

Senior Lecturer, School of Pharmacy and Pharmaceutical Sciences (Oct 97-present)
Lecturer in Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences (1994 - 97)
Lecturer, Department of Pharmaceutical Sciences, Aston University (1987 - 1994)
Visiting scientist, Cancer Research Institute and Department of Chemistry (Professor GR Pettit), Arizona State University, USA (1994)
Lister Fellow (1989-1995)
Visiting scientist and Postdoctoral fellow, Department of Chemistry (Professor JR Knowles), Harvard University, USA(1985 - 1991)

Awards

Dunlop Polymer Prize (1982)
Lilly Prize for Pharmaceutical Excellence (1993)

Recent Publications

Spiers ID, Barker CJ, Chung S-K, Chang Y-T, Freeman S, Gardiner JM, Hirst PH, Lambert PA,
Michell RH, Poyner DR, Schwalbe CH, Smith AW and Solomons KRH.
Synthesis and iron binding studies of myo-inositol 1,2,3-trisphosphate
and D/L-myo-inositol 1,2-bisphosphate, and iron binding studies of all myo-inositol tetrakisphosphates.
Carbohydr. Res 1996, 282, 81-99

Solomons KRH, Freeman S, Poyner DR and Yafai F.
Synthesis of 3,4,5,6-tetrakisphosphates of DL-1,2-dideoxy-,1,2-difluoro-ismyo-inositol
and DL-1,2-dideoxy-1,2-difluoro-scyllo-inositol as analogues of DLmyo-inositol 3,4,5,6-tetrakisphosphate.
J. Chem. Soc. Perkin Trans.1, 1996, 1845-1851.

Briggs AD, Camplo M, Freeman S, Lundstrom J and Pring B.G.
Acyloxymethyl and 4-acyloxybenzyl diester prodrugs of phosphonoformate.
Tetrahedron, 1996, 52 ,14937-14950.

Briggs AD, Camplo M, Freeman S, Lundstrom J and Pring B.
S-Acylthioethyl prodrugs of phosphonoformate.
Eur. J. Pharm. Sci., 1997,5,199-208.

Spiers ID, Schwalbe CH, Blake AJ, Solomons KRH and Freeman S.
Structure of ()-1,2;4,5-di-O-cyclohexylidene myo-inositol and synthesis of myo-inositol 3-phosphate via its phosphorylation with (2R, 4S, 5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one.
Carbohy Res. 1997, 302 ,43-51.

Freeman S and Ross KC.
Prodrug design for phosphates and phosphonates
Progress in Medicinal Chemistry, 1997, 34, 111-147(REVIEW)

Xie W, Solomons KRH, Freeman S, Kaetzel MA, Bruzik KS, Nelson DJ and Shears SB. Regulation of Ca2+ dependent C1 conductance in a human colonic epithelial cell line (T84): cross-talk between Ins (3,4,5,6) P4 and protein phosphatases.  J.Physiol, 1998, 510.3, 661-673.

Solomons KRH, Freeman S, Schwalbe CH, Shears SB, Nelson DJ, Xie W, Bruzik S and Kaetzel MA. Synthesis of D-1,2- dideoxy-1,2-difluoro-myo-inositol 3,4,5,6-tetrakisphosphate and its enanationer as analogues of myo-inositol 3,4,5,6-tetrakisphosphate Carbohydr. Res, 1998,309,337-343.

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