EUFEPS Fourth International Conference on

Drug Absorption

Towards Prediction and Enhancement of Oral Drug Absorption in Man
EDAF

Programme

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Friday 13 June

Welcome and Introduction

Laurie Prescott/Malcolm Rowland

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Session 1

Mechanisms Involved in Drug Absorption

(Chairmen - Laurie Prescott/Peter Dadonna)

The gastrointestinal tract - a modern view

Ernest Wright (USA)

Absorption of small molecules

Barry Hirst (UK)

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Break - Posters

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Absorption of oligonucleotides

Stanley Crooke (USA)

Absorption of macromolecules

To be announced

Efflux proteins and drug metabolism

Les Benet (USA)

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Lunch - Posters

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Session 2

Tools for Studying and Predicting

Human Drug Absorption

(Chairmen - Malcolm Rowland/Jacky Vonderscher)

Intestinal cell monolayers - Caco2 and beyond

Per Artusson (Sweden)

Are Caco2 cells predictive of transport and/or

metabolic properties of mammalian intestinal tissues?

Werner Rubas (USA)

Whole animal models for oral drug absorption

Jennifer Dressman (Germany)

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Break - Posters

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Regional intestinal perfusion in humans: an approach to study molecular mechanisms of intestinal membrane transport of drugs in vivo

Hans Lennern?s (Sweden)

Non-invasive techniques to study human drug absorption

Ian Wilding (UK)

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End of Session 2

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Evening Reception

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Saturday 14 June

Session 3

Predicting Drug Absorption from

Structural and Physicochemical Information

(Chairmen - Ron Borchardt/Norman Ho)

Biophysical models and approaches

Norman Ho(USA)/Phil Burton (USA)

Paracellular permeation

Malcolm Rowland (UK)

Active intestinal transport - peptide and monocarboxylate drugs

Akira Tsuji (Japan)

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Break - Posters

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Application of physicochemical methods to prediction of oral drug absorption

J Van de Waaterbeemd (Switzerland)

Drug dissolution and absorption: application to prediction and regulation

Gordon Amidon (USA)

Computational approach to potential absorption problems: analysis of human data

Christopher Lipinski (USA)

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Lunch - Posters

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Session 4

Overcoming Oral Absorption Problems

(Chairmen - Gordon Amidon/Mistura Hashida)

Formulation strategies for poorly water soluble drugs

Larry Sternson (USA)

Formulation strategies for water soluble drugs

Hans Junginger (The Netherlands)

Application of the prodrug principle

Ron Borchardt (USA)

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Break - Posters

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Enhancing delivery of peptides/ oligonucleotides

Bob Davis (UK)

Enhancing delivery of macromolecules

To be announced

Gene therapy expression and enhancement in

the gut

Peter Daddona (USA)

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End of session 4

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Conference Dinner

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Sunday 15 June

Session 5

Integrating Discovery and

Development - Case Histories

(Chairman - Douwe Breimer)

Combinatorial screening approaches for selection of development candidates &endash; experiences within SmithKline Beecham

Phil Smith (USA)

Experiences within Glaxo Wellcome

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Break

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Session 6

Regulatory Issues and Guidelines

(Chairman - Les Benet)

"The Biopharmaceutical Classification System (BCS): How useful is it in assessing and maintaining

quality of oral dosage forms?"

Research to policy: evolution of the BCS in regulatory decision making

Larry Lesko (USA)

Analysis of NDA and ANDA data base for validation

Ajaz Hussain (USA)

What more needs to be done? - general discussion

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Closing address -

Laurie Prescott/Malcolm Rowland

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12.30hrs END OF CONFERENCE

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